The upstream process development team holds rich experiences in the development of avariety of protein molecules, including: MAbs, bsAbs, recombinant proteins and fusion proteins. With a well validated bioreactor process development platform, we can swiftly achieve cultivation parameter screening, optimization and finalization. In the meantime, we can develop different process types based on diverse needs of the customer using both stirred or orbital shaken bioreactors.

DoE concept has been implemented within the whole development process and PAT tool usage, rigorous variable assessment, flexible development strategy, glycosylation profile adjustment and expression titer boosting will reduce development risks, maintain key quality attributes and ultimately ensure the quality consistency while transition from lab scale to batch scale manufacturing.